Oncobites | Abstracts ESMO 24

ESMO 2024

PULMÓN

ESTADIO TEMPRANO

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Evaluation of safety and feasibility of adjuvant

chemotherapy in elderly patients with primary non-small

cell lung cancer

1224P

Neoadjuvant Tislelizumab (TIS) Plus Chemotherapy (CT)

with Adjuvant TIS vs. Neoadjuvant Placebo (PBO) Plus CT

with Adjuvant PBO in Resectable Non-Small Cell Lung

Cancer (NSCLC): Patient-Reported Outcomes (PRO) in the

RATIONALE-315 Trial

1213P

Neoadjuvant nivolumab and nivolumab+ipilimumab in

resectable non-small cell lung cancer: Combined analysis of

5-year outcomes from NEOSTAR and CA209-159

1209P

Trial in Progress: Combining Immunotherapy with Trop2

ADc in Early stage non-small cell Lung cancer (CITADEL)

1238TiP

NEO-PIONEER:Neoadjuvant Hypofractionated Radiotherapy

plus Tislelizumab with Anlotinib Followed by Adjuvant

Tislelizumab with Anlotinib in Patients with Resectable

Non-Small Cell Lung Cancer (NSCLC): A Phase II Trial in

Progress

1239TiP

Neoadjuvant nivolumab monotherapy for high-risk clinical

stage I non-small cell lung cancer: A phase 2 POTENTIAL

study

1207MO

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ESMO 2024

PULMÓN

LOCALMENTE AVANZADO O METASTÁSICO

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MET×MET bispecific antibody davutamig (REGN5093) for

MET-altered advanced non-small cell lung cancer (aNSCLC):

Update from a first-in-human (FIH) study(aNSCLC)

1302P

Risk model for overall survival (OS) based on composite

patient-reported outcomes (PROs) in aNSCLC patients

treated with first-line (1L) cemiplimab-based therapy

1853P

ALINA: exploratory biomarker analyses in patients (pts) with

resected ALK+ non-small cell lung cancer (NSCLC) treated

with adjuvant alectinib vs chemotherapy (chemo)

1206MO

Associations of ctDNA clearance (CL) during neoadjuvant Tx

with pathological response and event-free survival (EFS) in

pts with resectable NSCLC (R-NSCLC): Expanded

analyses from AEGEAN

LBA49

CCTG BR.31: A global, double-blind placebo-controlled,

randomized phase III study of adjuvant durvalumab in

completely resected non-small cell lung cancer (NSCLC)

LBA48

Perioperative nivolumab (NIVO) v placebo (PBO) in patients

(pts) with resectable NSCLC: Clinical update from the phase

III CheckMate 77T study

LBA50

ESTADIO TEMPRANO

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ESMO 2024

PULMÓN

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Updated efficacy and safety from the phase II PHAROS

study of encorafenib plus

binimetinib in patients with BRAF V600E-mutant

metastatic NSCLC (mNSCLC)

LBA56

Mechanisms of acquired resistance to first-line

amivantamab plus lazertinib versus osimertinib in patients

with EGFR-mutant advanced non-small cell lung cancer:

An early analysis from the phase III MARIPOSA study

LBA55

Osimertinib (osi) after definitive chemoradiotherapy (CRT)

in unresectable (UR) stg III EGFRm NSCLC: Analyses of CNS

and distant progression from the Phase 3 LAURA study

1241MO

Precision immuno-oncology for advanced non-small cell

lung cancer (NSCLC) patients with PD-(L)1 inhibitors

resistance (PIONeeR): A phase Ib/IIa clinical trial targeting

identified resistance pathways

LBA8

Adagrasib (ADA) vs docetaxel (DOCE) in patients (pts) with

KRASG12C-mutated advanced NSCLC and baseline brain

metastases (BM): Results from KRYSTAL-12

LBA57

ABBV-400 a c-Met protein-targeting antibody-drug

conjugate (ADC), in patients (Pts) with advanced EGFR

wildtype (WT) non-squamous (NSQ) non-small cell lung

cancer (NSCLC): Results from a phase I study

1257MO

LOCALMENTE AVANZADO O METASTÁSICO

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ESMO 2024

PULMÓN

OTROS TUMORES DEL TÓRAX

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PECATI: A phase II trial to evaluate the efficacy and safety

of lenvatinib in combination with pembrolizumab in

pretreated advanced B3-thymoma and thymic carcinoma

LBA83

ARTIMES: Automated Response evaluation to Treatment In

MESothelioma

1910MO

Updated survival and vaccine response from the NIPU trial:

A randomised, phase II study evaluating nivolumab and

ipilimumab with or without UV1 vaccination in patients with

pleural mesothelioma

1917P

Molecular analysis of mesothelioma reveals mutations as

prognostic biomarkers for patients treated with the

combination of ipilimumab and nivolumab

1921P

Nintedanib(N) as switch maintenance treatment in

malignant pleural mesothelioma (MPM) (NEMO): A

double-blind randomized phase II trial (EORTC-08112-LCG)

1914P

Durvalumab (D) as consolidation therapy in limited-stage

SCLC (LS-SCLC): Outcomes by prior concurrent

chemoradiotherapy (cCRT) regimen and prophylactic

cranial irradiation (PCI) use in the ADRIATIC trial

LBA81

LOCALMENTE AVANZADO O METASTÁSICO

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ESMO 2024

GINECOLÓGICO

OVARIO

Datopotamab deruxtecan (Dato-DXd) in patients with

endometrial (EC) or ovarian cancer (OC): results from the

Phase 2 TROPION-PanTumor03 study

714MO

Mirvetuximab Soravtansine (MIRV) in Recurrent

Platinum-Sensitive Ovarian Cancer (PSOC) with High Folate

Receptor-Alpha (FRα) Expression: Results from the PICCOLO

Trial

718MO

Phase 3 MIRASOL Trial: Updated Overall Survival Results of

Mirvetuximab Soravtansine (MIRV) vs. Investigator’s Choice

Chemotherapy (ICC) in Patients (pts) with

Platinum-Resistant Ovarian Cancer (PROC) and High Folate

Receptor-Alpha (FRα) Expression

746P

Final overall survival (OS) from the Phase III

ATALANTE/ENGOT-ov29 trial evaluating atezolizumab (Atz)

versus placebo with standard chemotherapy (Cx) plus

bevacizumab (bev) in ovarian cancer (OC) patients (pts) with

platinum-sensitive relapse (PSR)

712MO

SOLACE2: A Phase 2 randomized trial of Olaparib (O) and

Durvalumab (D) with or without low dose

cyclophosphamide (LDCy) in platinum-sensitive recurrent

ovarian cancer (PSROC)

747P

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ESMO 2024

GINECOLÓGICO

OVARIO

A Phase 1/2 study of Rinatabart Sesutecan (Rina-S) in

Patients with Advanced Ovarian or Endometrial Cancer

719MO

ATHENA-COMBO, a phase 3, randomized trial comparing

rucaparib (RUCA) + nivolumab (NIVO) combination therapy

vs RUCA monotherapy as maintenance treatment in

patients (pts) with newly diagnosed ovarian cancer (OC)

LBA30

ICON9: International phase III randomized study to evaluate

the efficacy of maintenance therapy with olaparib and

cediranib or olaparib alone in patients with relapsed

platinum-sensitive ovarian cancer following a response to

platinum-based chemotherapy

LBA33

Outcomes of BRCA and in-house homologous

recombination deficiency (HRD) testing in women with

ovarian and breast cancer: A multicentre registry study

LBA64

Final overall survival (OS) in patients (pts) with newly

diagnosed advanced ovarian cancer (aOC) treated with

niraparib (nir) first-line (1L) maintenance: results from

PRIMA/ENGOT-OV26/GOG-3012

LBA29

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ESMO 2024

GINECOLÓGICO

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ENDOMETRIAL

Post-Progression Survival Outcomes in Patients (pts) with

Primary Advanced or Recurrent Endometrial Cancer

(pA/rEC) in the ENGOT-EN6-NSGO/GOG-3031/RUBY Trial

Who Received Follow-up Immunotherapy

731P

Impact of investigator-assessed response on overall survival

(OS) in patients (pts) with primary advanced or recurrent

endometrial cancer (pA/rEC) in the

ENGOT-EN6-NSGO/GOG3031/RUBY trial

734P

Durvalumab + carboplatin/paclitaxel (CP) followed by

durvalumab ± olaparib as a first-line treatment for

endometrial cancer (EC): progression-free survival (PFS) by

clinical factors in DUO-E

732P

Efficacy and safety of sacituzumab govitecan (SG) in

patients with advanced/metastatic endometrial cancer (EC):

updated results from TROPiCS-03

733P

Validation of circulating tumor DNA for prognostication and

monitoring in metastatic endometrial carcinoma: ancillary

results from the phase II randomized GINECO trial UTOLA

730P

Characterization of Tumor Response With Lenvatinib Plus

Pembrolizumab (LEN + Pembro) in the

ENGOT-en9/LEAP-001 Study

737P

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ESMO 2024

GINECOLÓGICO

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ENDOMETRIAL

Immunotherapy plus Chemotherapy in the First-line

Treatment for Primary Advanced or Recurrent Endometrial

Cancer: An Extracted Individual Patient Data and Trial-Level

Meta-Analysis

743P

Safety and efficacy of sacituzumab tirumotecan (sac-TMT)

in patients (pts) with previously treated advanced

endometrial carcinoma (EC) and ovarian cancer (OC) from

a phase II study

715MO

ENGOT-en11/GOG-3053/KEYNOTE-B21: A phase III study of

pembrolizumab or placebo in combination with adjuvant

chemotherapy with or without radiotherapy in patients

with newly diagnosed, high-risk endometrial cancer.

LBA28

Comparison of the Idylla™ Microsatellite Instability (MSI)

test with a gold standard MSI test and mismatch repair

immunohistochemistry in endometrial cancer

741P

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ESMO 2024

GINECOLÓGICO

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CERVICAL

Long-term patient-reported outcomes (PROs) with

atezolizumab (atezo) + bevacizumab (bev) and

chemotherapy (CT) for metastatic, persistent or recurrent

cervical cancer (R/M CC): BEATcc (ENGOT-Cx10/GEICO

68-C/JGOG1084/GOG-3030) randomised phase 3 trial

722P

A phase II study of cadonilimab plus chemotherapy in

persistent recurrent/ metastatic cervical cancer patients

who failed previous immuno/chemotherapy

723P

Chemotherapy plus tislelizumab in young patients with

cervical cancer preserve fertility: a phase II study

728P

Efficacy and Safety of Pembrolizumab plus Olaparib

Combination Therapy in Recurrent Cervical Cancer

Progressed on Platinum-Based Chemotherapy: Results

from the phase II trial of GOTIC-025

726P

Preliminary Outcomes from a Phase 1b/2 Study of the Highly

Potent PI3K-mTOR Dual Inhibitor WX390 Combined with

Toripalimab in Patients with Advanced Cervical Cancer

724P

Treatment of patients with metastatic or relapsed cervical

cancer: results from a quality assurance program of the

AGO Study Group

725P

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ESMO 2024

GINECOLÓGICO

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CERVICAL

Induction chemotherapy followed by chemoradiation in

locally advanced cervical cancer: quality of life outcomes of

the GCIG INTERLACE trial.

710MO

Efficacy and Safety of Sacituzumab Tirumotecan

(sac-TMT) Plus Pembrolizumab in Patients with Recurrent

or Metastatic Cervical Cancer

716MO

Primary results from BEATcc (ENGOT-Cx10/GEICO

68-C/JGOG1084/GOG-3030), a randomised phase III trial of

first-line atezolizumab (atezo) combined with a platinum

doublet and bevacizumab (bev) for metastatic (stage IVB),

persistent or recurrent cervical cancer (R/M CC)

VP5-

2023

Pembrolizumab plus chemoradiotherapy for high-risk

locally advanced cervical cancer: Overall survival results

from the randomized, double-blind, phase 3

ENGOT-cx11/GOG-3047/KEYNOTE-A18 study

709O

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